Paul Thomen

Friday, 30 August 2013

New Study: GPCR screening and profiling Market Trends 2013

The report GPCR Screening & Profiling Trends 2013 by HTStec Ltd. is now available at with report name in subject line and your contact details to purchase this report or get your questions answered.

This market report summarizes the results of HTStec's 5th industry-wide global web-based benchmarking survey on GPCR screening and profiling carried out in August 2013. The survey was initiated by HTStec as part of its tracking of life science marketplaces. The questionnaire was compiled to meet the needs, requirements and interests of the GPCR vendor community. The objectives were to comprehensively document current practices and preferences in GPCR primary screening and compound profiling, and to understand future user requirements, particularly with respect to the need for new assays, approaches and the use of outsourced services. The aim was to compile a reference document on GPCR screening and profiling metrics, which could be directly compared with HTStec's previous reports (the last one on GPCRs was published in October 2010). Equal emphasis was given to soliciting opinion from Pharma, Biotech and Academic Research market segments in both North America and Europe.

The survey looked at both in house and outsourced GPCR primary screening and compound profiling, as practiced today (2013) and in some cases as predicted for the future (2015). Specifically the following were investigated: whether the number of GPCR primary screening targets or programs under investigation is changing; the proportion of GPCR screens that are cell-based and orphan receptors; use of different methods for assaying GPCR activation; preferred assay readout technology and supplier for GPCR screening; proportion of GPCR Ca2+ flux assays that are fluorescence-based; number of GPCR primary screens and wells per screen; approach to GPCR profiling; preferred assay readout technology and supplier for GPCR profiling; size of in house profiling panels and total wells profiled in house per year; how receptor panels are chosen; level of interest in outsourcing; methods of assaying GPCR activation that respondents wish to access by outsourcing; type of GPCR panels most interested to access at a fee-for-service provider; typical sizes of outsourced GPCR profiling panels used and total wells profiled per year at a fee-for-service providers; most trusted and most used providers of outsourced GPCR assay services; in house and outsourced budgets for GPCR screening and profiling; the breakdown of in house budgets; average costs paid per well for GPCR screening and profiling; level of interest in new assays/approaches for GPCR screening and profiling; suitability of available tools for new assays/approaches for GPCR screening and profiling; the proportion of GPCR assays that are made using primary cell lines and stem cell derived phenotypes; main barriers to the implementation of a new GPCR screening technology; where a GPCR reagent developer or assay fee-for-service provider should focus their efforts in the future; preferred way of sourcing GPCR expressing cell lines and the factors that drive decision making when sourcing; and any unmet needs in GPCR screening & profiling today.

The main questionnaire consisted of 30 multi-choice questions and 1 open-ended question. In addition, there were 7 questions related solely to survey demographics. The survey collected 96 validated responses, of these 66% provided comprehensive input. Survey responses were geographically split: 61% North America; 27% Europe; 7% Asia (excluding Japan); and 5% Japan. Survey respondents were drawn from persons or groups involved in GPCR primary screening and compound profiling in house and the outsourcing of GPCR testing to fee-for-service providers. Respondents came from 21 Large Pharma; 21 University; 17 Biotech; 12 Medium-Small Pharma; 9 Hospital/Clinic/Medical School; 6 Research Institute; 5 Academic Screening Center; 4 Government Laboratory; and 1 Other.

Most survey respondents had a senior job role or position which was in descending order: 17 senior scientists/researchers; 17 principal investigators; 13 research scientists; 13 professors/assistant professors; 8 directors; 7 section/group leaders; 7 department heads; 1 graduate/PhD student; 1 vice president; and 1 outsourcing manager.

Respondents main group activities were: 27 basic research; 23 a combination of drug discovery roles; 11 assay development; 10 primary screening (HTS); 8 applied research; 7 hits-to-leads (lead optimization); 6 therapeutic areas; 2 secondary screening; and 2 compound profiling. Survey results were expressed as an average of all survey respondents. In addition, where appropriate the data was fully reanalyzed after sub-division into the following 5 survey groups: 1) Pharma; 2) Biotech; 3) Academic Research; 4) Europe; and 5) North America.

The median number of GPCR primary screening targets/programs under investigation in 2013 was 3. 70% of GPCR primary screens were cell-based and 17% were orphan receptors in 2013. In 2013 the relative use of different methods used to study GPCR activation was: 24% binding assays; 16% cAMP or cGMP assays; 13% Ca2+ flux/mobilization assays; 12% β-arrestin recruitment or receptor internalization; and 11% reporter gene assays. All other methods had less than 10% use. The preferred GPCR readout technologies and suppliers for GPCR activation assays used in both primary screening and compound profiling were as follows: binding assays - radiometric from PerkinElmer; β-arrestin recruitment or receptor internalization - chemiluminescence from DiscoveRx; label-free cellular changes & translocation - label-free readout from Corning; GTP

γS - radiometric from PerkinElmer; reporter gene assays - glow luminescence from Promega ; Ca2+ flux/mobilization assays - fluorescence intensity from Molecular Devices; IP3 or IP1 - TR-FRET from Cisbio; cAMP or cGMP Assays - TR-FRET from Cisbio; ERK phosphorylation assays - TR-FRET from PerkinElmer; and other phenotypic readouts - various readouts and suppliers. 44% of all GPCR Ca2+ flux/mobilization assays were fluorescence-based in 2013.

Median in house 2013 GPCR screening metrics were: 3 primary screens/year and 10K-25K wells/screen. The preferred approach to GPCR profiling was to profile selected lead compounds only in house. Median in house 2013 GPCR profiling metrics were: 2 to 3 new receptors added to the panel per year; a total of 6 to 10 receptors per panel; and 5K-10K wells profiled per year. Respondents did not have a preferred way of choosing panels when running GPCR compound profiles.

42% of respondents might outsource GPCR primary screening versus 57% might outsource GPCR compound profiling today (2013). Most want to access primary screening using β-arrestin recruitment or receptor internalization methods and compound profiling using binding assays methods. The types of GPCR panels respondents were most interested in accessing for outsourced compound profiling today (2013) were those that included all known GPCRs available. The median outsourced 2013 GPCR profiling metrics were: 6 to 10 receptors/profile and 1K-15K wells profiled per year.

PerkinElmer, Life Technologies and Cerep were ranked the most trusted and most used outsourced GPCR fee-for-service providers. Although no provider stood out way above all others. The median GPCR primary screening budget allocations in 2013 were $10K-$25K/lab in house and $5K-$10K/lab outsourced. The biggest expenditure was on bulk reagents & pre-packaged assay kits.

The median GPCR compound profiling budget allocations in 2013 were $10K-$25K/lab in house and lt;$5K/lab outsourced. The biggest expenditure was on bulk reagents & pre-packaged assay kits. The median cost/well for GPCR primary screening in 2013 was $0.35-$0.50/well both in house & outsourced.

The median cost per well for GPCR compound profiling in 2013 was $0.35-$0.5/well in house versus $0.50-$0.75/well outsourced. Functional selectivity was rated the assay/approach for GPCR primary screening and compound profiling that respondents had most interest in using/evaluating. Receptor internalization and trafficking was the assay/approach for GPCR primary screening and compound profiling where the suitability of currently available tools was rated most effective.

24% of GPCR assays were made using primary cells and 6% using stem cell derived phenotypes in 2013. Instrumentation/technology costs were the most significant barrier to new GPCR technology adoption. Receptor internalization and trafficking was rated as the area where respondents thought GPCR reagent developers should focus their efforts going forward. Offer screening services in more biologically relevant cellular backgrounds was rated as the area where respondents thought GPCR fee-for service providers should focus their efforts going forward.

Most respondents prefer to source GPCR expressing cell lines by making them in house. Cost and time were ranked the most important factors when making/sourcing GPCR expressing cell lines. Feedback on some unmet needs that exist today in GPCR screening and profiling were documented. Several bottom-up models were developed around the respondent's annual budgets to estimate the global markets for GPCR screening and profiling. In 2013 these markets were estimated to be as follows: in house GPCR primary screening reagents - $144M; in house GPCR compound profiling reagents - $28M; outsourced GPCR primary screening - $20M; and outsourced GPCR compound profiling - $24M. The market was segmented by organization and geography. CAGR estimates for 2015 were made for the market segments.

The full report provides the data, details of the breakdown of the responses for each question, its segmentation and the estimates for the future (2015). It also highlights some interesting differences, particularly between Pharma versus the other survey groups.

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For more details contact Mr. Priyank Tiwari: / +18883915441

Thursday, 29 August 2013

Global Complex Event Processing Market (CEP) Forecast & Analysis 2013-2018

The report Complex Event Processing (CEP) Market [Algorithmic Trading, Fraud Detection, Sentiment Analysis, Supply Chain Optimization, Transportation and Logistics, Revenue Assurance, Emergency Response Services] Worldwide Market Forecast & Analysis (2013 - 2018) by MarketsandMarkets is now available at with report name in subject line and your contact details to purchase this report or get your questions answered.

As current market scenario is increasingly competitive and highly complex, thereby demands to execute large business deals, operation level decisions and recognizing risk events ‘before hand’ is even more challenging. As well, it is essential to maintain a minimum amount of latency alongside to have sustainable business environment. Further, the circumstances are intensified by an ever-expanding service industry generating huge data volumes from an enormous collection of distinct sources. It is highly impractical to expect human resource to supervise this huge data, process and represent the event outcome for any organization. Therefore, Complex Event Processing (CEP) technology has shown its market importance of low-latency filtering, aggregating, correlating, and computing, based on a broad collection of chronological and real-time streaming data. Complex Event Processing plays an important role in financial industry by enhancing capabilities in constructing cautious trading decisions by offering services such as algorithmic trading, liquidity aggregation, surveillance tools and risk management solutions. Moreover, CEP solutions also have applications in industries such as telecommunication, healthcare, retail and energy.

Major players include Oracle, IBM, Microsoft, Software AG, SAP, Tibco and many others. The report provides a comprehensive business case analysis along with information on key market drivers, restraints, opportunities, challenges and key issues in Complex Event Processing (CEP) market. The report aims at estimating the current market size and the future growth potential of this market across components, verticals & geographies.

The research report provides an overview, overall market study and segmentation based on various technologies, applications, regions and verticals for the global CEP market. Furthermore, the report gives detailed analysis on global trends and forecasts, competitive landscape and analysis on VC funding and M&A, related to CEP market.

The market research report categorizes the global Complex Event Processing market on the basis of types, services, verticals, applications and regions. It also forecasts volumes, revenues and analyzes trends in each of the submarkets:

On the Basis of Types:
We have segmented it on the basis of detection oriented, operation oriented and hybrid based CEP technologies currently available in the CEP market.

On the Basis of Services:
This segment includes services such as installation and maintenance, training and certification, customer support and other services. Other services are industry standards such as HL7, HIPAA, eFinancial, SWIFT, BASEL II, UCCNet, RosettaNet and many other based on the vertical related to the client.

On the basis of Applications:
We have segmented vertical centric applications such as BFSI: algorithmic trading, electronic transaction monitoring, dynamic pre‐trade analytics, data enrichment, fraud detection, governance, risk and compliance (GRC); healthcare: self-service proactive monitoring and alerting and governance, risk and compliance (GRC); transportation and logistics: asset management and predictive scheduling and toll system management; IT and telecommunication: mobile billboards, revenue assurance, infrastructure management and predictive CDR assessment; retail: inventory optimization, shoplifting detection and real-time marketing and customer engagement; energy and utilities: oil and gas operation management and nuclear crisis and smart grid energy management; manufacturing: shop floor automation and operational failure detection, infrastructure management and supply chain optimization; government, defense and aerospace: Intelligence and Security, emergency response services and geo-fencing and geospatial analysis; Others: includes education and research.

On the Basis of Verticals:
This segment covers industry verticals that are currently having prominent market share in the CEP technology. These verticals are BFSI, transportation and logistics, healthcare, manufacturing, IT and telecommunication, energy and utilities, retail, government, defense and aerospace and ‘Others’ (it includes airports and railroad related industry which is still in adoption phase of CEP technology).

On the Basis of Regions:
Regional segmentation covers North America (NA), Latin America (LA), Europe (EU), Middle East and Africa (MEA) and Asia Pacific (APAC – includes Japan).

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Major points of table of content
10 Company Profiles (Overview, Products and Services, Financials, SWOT Analysis, Strategies and Insights)* 
10.1 Cisco
10.2 Clear Priority
10.3 EMC
10.4 Fujitsu
10.5 Huawei
10.6 IBM
10.7 Informatica
10.8 Lockheed Martin
10.9 Microsoft
10.10 Oracle
10.11 Redhat
10.12 SAP
10.13 SAS
10.14 Software AG
10.15 Tibco
10.16 Other Innovators
10.16.1 Automic Software
10.16.2 Modular Streams
10.16.3 Nastel Technologies
10.16.4 Onemarketdata
10.16.5 Radware
10.16.6 SL Corporation
10.16.7 Traak System
10.16.8 Vitria Technologies
10.16.9 Westglobal

Global Application Delivery Network (ADN) Market Advancements Forecasts & Analysis (2013 - 2018)

The report Application Delivery Network (ADN) Market [Application delivery controllers (ADC), WAN Optimization controllers (WOC), Application Security Equipments, Application Gateways] Global Advancements, Worldwide Forecasts & Analysis (2013 - 2018) by MarketsandMarkets is now available at with report name in subject line and your contact details to purchase this report or get your questions answered.

Globally, companies are increasingly deploying web-based collaboration applications such as Microsoft Outlook and SharePoint, Enterprise Resource Planning (ERP) applications such as SAP and Oracle, and static content sharing to leverage the machine-to-machine interactions between distributed enterprises. This makes networking a very crucial part of various businesses. Companies are facing conflicts due to existing corporate network bottlenecks in moving their business-critical applications over the Internet to minimize the cost and complexities associated with the data center deployments and to ensure higher application performance and security.

With continued expansion, enterprises are adopting Bring-Your-Own-Device (BYOD), which enable employees to share business-critical data over mobile devices such as smart phones, iPads, laptops, and others. However, existing corporate networks are not designed to handle large application traffic. To address these requirements, the network vendors have come up with the concept of Application Delivery Network (ADN) that offloads application provisioning to a highly secure external network that provides reliable application delivery without load and latency.

Application Delivery Network overcomes the networking bottlenecks and addresses the demand for greater application mobility and security in distributed enterprises. ADN classifies and prioritizes the business applications, content, and users in real-time, accelerates the applications across distributed enterprises, and provides security against malicious applications and content. While controlling rising network management costs, ADN can deliver fast, secure, and available applications across the distributed enterprise.

Application Delivery Network technology is a suite of technologies that can be deployed in corporate networks or data centers and are used to provide application availability, visibility, and security. In data centers, Application Delivery Controllers (ADCs) are used to distribute the web traffic to various servers located at distant places. Being placed in between cluster of web servers, it also facilitates load balancing when there is a demand for mix of applications across various locations in the network. ADN automatically routes requests along the next-best path, when degradation along one path occurs. ADN helps in reducing payload by using optimized connections for faster speeds and less bandwidth usage, while also reducing bandwidth and server costs while improving the customer experience.

Prominent vendors in the Application Delivery Network space include F5 Networks, Citrix, Cisco, Radware, while companies such as Barracuda Networks, Fortinet, and Edge Cast emerge as key innovators in this space. The ADN market research report analyzes market dynamics, future roadmaps, and global trends, and also provides competitive intelligence and forecasts over the next 5 years.

The report broadly comprises ADN product segments: controllers, application security equipment, and application gateways; by end-users: Small- and Medium-Sized Businesses (SMB) and enterprises; by end-user environments: cloud service providers, telecommunications service providers, and enterprises; by verticals: high-tech, education, media and entertainment, government, Banking, Financial Services, and Insurance (BFSI), retail, and others; by regions: North America (NA), Europe (EU), Asia Pacific (APAC), Middle East and Africa (MEA), and Latin America (LA).

This research report segments and categorizes the global ADN market on the basis of the following submarkets:
On the basis of Product Segments:
Controllers, ADCs, WOCs, Secure access gateways, Security equipment

On the basis of End-User Environments:
Enterprises, Telecommunications service providers, Cloud service providers

On the basis of End-Users:
Enterprises, SMB

On the basis of Industry Verticals:
High-Tech, Education, Media and entertainment, BFSI, Government, Retail, Others
On the basis of Regions:
North America (NA), Europe (EU), Asia Pacific and Japan (APAC), Middle East and Africa (MEA), Latin America (LA)

Browse more reports on IT & Telecommunication Market @

Major points of table of content
11 Company Profiles (Mnm View, Overview, Products And Services, Financials, Strategies And Insights)*
11.1 Array Networks
11.2 Aryaka Networks
11.3 A10 Networks
11.4 Blue Coat Systems
11.5 Brocade
11.6 Cisco Systems, Inc.
11.7 Citrix Systems, Inc.
11.8 Dell, Inc.
11.9 F5 Networks
11.10 Hewlett-Packard (HP)
11.11 Juniper Networks
11.12 Oracle Corporation
11.13 Radware
11.14 Riverbed Technology
11.15 Verizon
11.16 Other Key Innovators
11.16.1 Barracuda Networks
11.16.2 Edgecast Networks
11.16.3 Fortinet
11.16.4 Networx Australia
11.16.5 Network Instruments
11.16.6 Procera Networks
11.16.7 Quosmos
11.16.8 Sangfor
11.16.9 Coyote Point
11.16.10 Synercomm